ViaZen
Menopause
Treatment duration:
3 to 6 consecutive months
Therapeutic indications:
This product can be used
when the menstrual cycle starts to become irregular with or
without the appearance of the other clinical signs associated
with the menopause.
Note:
Viazen
Menopause is recommended in presence of soya allergy, because
the ISOFLAVONES included in this formula originated from the Red
Clover and not from soya’s bean. This product is free of wheat,
soya, corn, yeast, peanut, gluten, egg and dairy products. It
does not contain preservatives, sweeteners, colouring agents,
artificial flavours and is exempt of GMO.
Mechanism of action:
Viazen Menopause helps
to relieve menopause discomforts in several ways. Red clover
isoflavones seem to be responsible for the majority of the
therapeutic benefits while contributing to control the
oestrogenic activity.
This effect is
associated with affinity (due to the similarity of their
chemical structure) of the isoflavones to estradiol receptors
and their capacity to act as agonists and antagonists.
Biochanine and formononetine are the main isoflavones present in
the red clover.
These molecules are
respectively metabolized in vivo in genisteine and diadzeine.
Moreover, these four isoflavones have an anti-androgenic
activity. It seems that the red clover also has a regulating
action on the RNA messenger of progesterone receptor. Black
cohosh is approved by the Commission E and the World Health
Organization, as a specific treatment to relieve menopause
symptoms, and it is largely widespread in Europe.
The triterpenic
glycosides, the phenylpropanoids, the organic acids, the
polyphenols and the lignanes are the main active components
having shown a pharmacological activity. Black cohosh doesn’t
seem to have significant direct oestrogenic effects, but rather
an anti-oestrogenic effect. Its therapeutic action would also be
associated to a serotoninergic effect and as an agonist effect
to opiates receptors, which help reducing the physiological
stress associated to menopause.
Magnesium comes to
potentiate the regulation of the hormonal and nervous functions,
thus allowing the reduction of the stress level. The scientific
literature emphasizes that the oxidative stress (radical free >
antioxidants) is increased in the course of menopause, which is
associated with the process of ageing and the development of
degenerative diseases.
Viazen Menopause formula
includes several sources of antioxidants, in order to counter
this process. The alpha-lipoic acid (ALA) is an important
antioxidant. Its molecular structure enables to neutralize
several types of free radicals. This molecule also has the
capacity to recycle other antioxidants, including vitamin E,
vitamin C and the antioxidant enzyme glutathion, mainly
synthesized by the liver. Supporting liver detoxification
process ensures a more effective bio-transformation of
circulating oestrogens.
Several components of
black cohosh and red clover have also antioxidant activity. In
addition, black cohosh, red clover and magnesium offer a
protection against the loss of bone mass and thus contribute to
prevent the osteoporosis. Lastly, magnesium and the ALA are
necessary to energy production (ATP) and so will contribute to
reduce general tiredness, often present in the course of
menopause.
The ingredients’ synergy of Viazen Menopause is the key of the
effectiveness of this SUPERIOR FORMULA.
References :
Wuttke W
et al.
Maturitas. The Cimicifuga preparation BNO 1055 vs. conjugated
estrogens in a double-blind placebo-controlled study: effects on
menopause symptoms and bone markers. 2003 Mar 14;44 Suppl
1:S67-77. Radowicki S et al. Effectiveness and safety of the
treatment of menopausal syndrome with Cimicifuga racemosa dry
extract. Ginekol Pol. 2006. Sep;77(9):678-83. Nappi RE et al.
Efficiency of Cimicifuga racemosa on climacteric complaints : a
randomized study versus low-dose transdermal estradiol.
Gynecol
Endocrinol. 2005. Jan ;20(1) :30-5.
Mahady
GB. Black cohosh (Actea/Cimicifuga racemosa): review of the
clinical data for safety and efficacy in menopausal symptoms.
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Botanical and dietary supplements for mood and anxiety in
menopausal women. Menopause. 2007. May-Jun;14(3 Pt 1):541-9
Booth NL et al. The chemical and biologic profile of a red
clover (Trifolium pratense L.) phase II clinical extract. J
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Overk CR et
al.
Comparison of the in vitro estrogenic activities of compounds
from hops (Humulus lupulus) and red clover (Trifolium pratense).
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Effects
of a red clover extract (MF11RCE) on endometrium and sex
hormones in postmenopausal women.
Maturitas.
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Phytoestrogen supplements for the treatment of hot flashes: the
Isoflavone Colver Extract (ICE) Study: a randomized controlled
trial.
JAMA. 2003
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Menopause : a review on the role of oxygen stress and favorable
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May-Jun;42(3):289-306. Pou KM et al. Visceral and subcutaneous
adipose tissue volumes are cross-sectionally related to markers
of inflammation and oxidative stress: the Framingham Heart
Study. Circulation. 2007 Sep 11;116(11):1234-41. Beitner H.
Randomized, placebo-controlled, double blind study on the
clinical efficiency of a cream containing 5% alpha-lipoic acid
related to photoageing of facial skin. Br J Dermatol. 2003
Oct;149(4):841-9.
Pansini F
et al.
Oxidative stress, body fat composition, and endocrine status in
pre-and postmenopausal women. Menopause. 2007 Aug 9. Nielsen FH
et al. Dietary magnesium deficiency induces heart rhythm
changes, impairs glucose tolerance, and decreases serum
cholesterol in post menopausal women.
J Am Coll
Nutr. 2007 Apr;26(2):121-32.
Hachul
de Campos H et al. Sleep disturbances, oxidative stress and
cardiovascular risk parameters in postmenopausal women
complaining of insomnia. Climacteric. 2006 Aug;9)4): 312-9.
Fenichel P. Xénoestrogènes et cancer du sein : De nouveaux
facteurs de risque accessibles à la prévention ? Reprod. hum.
horm. 2005, vol. 18, no 1-2 (56 ref.), pp. 34-42.
Sohoni P, Sumpter JP. Several
environmental oestrogens are also anti-androgens. J Endocrinol
1998 Sep ;158(3) : 327-39. Olea N et al. Inadvertent exposure to
xenoestrogens. Eur J Cancer Prev 1998 Feb ; 7 Suppl 1 : 17-23.
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