Ménopause

• Consult a health care practitioner if:
  • symptoms persist or worsen
  • you have a liver disorder
  • you develop symptoms of liver trouble
• Do not use if you are pregnant or breastfeeding.

• Be aware in presence of liver disorders (hepatitis, cirrhosis).

• Be aware when antidepressive drugs are used, because it may exist interactions with Black Cohosh active components.

• ALA has hypoglycemic effect, so be aware in presence of antidiabete drugs.

• Take a few hours before or after taking other medication.

Comtraindications:

• Do not use with antidiabete, oestrogens, anticoagulants or Tamoxifen

ViaZen Menopause

Treatment duration:  3 to 6 consecutive months

Therapeutic indications:

This product can be used when the menstrual cycle starts to become irregular with or without the appearance of the other clinical signs associated with the menopause.

• Anxiety

• Bloating

• Breast tension

• Constipation

• Depression

• Drop or loss of libido

• Dysmenorrhoea : menstrual cycles modifications and spotting in the middle of the cycle

• Hair loss

• Heavy legs

• Heart palpitations

• Hot flushes

• Insomnia

• Irritability

• Joint pain

• Memory loss

• Migraine

• Mood swing

• Muscle cramps

• Nervousness

• Night sweat

• Skin dryness

• Stress

• Tiredness

• Vaginal dryness

• Weight gain

Note: Viazen Menopause is recommended in presence of soya allergy, because the ISOFLAVONES included in this formula originated from the Red Clover and not from soya’s bean. This product is free of wheat, soya, corn, yeast, peanut, gluten, egg and dairy products. It does not contain preservatives, sweeteners, colouring agents, artificial flavours and is exempt of GMO.

Mechanism of action:

Viazen Menopause helps to relieve menopause discomforts in several ways. Red clover isoflavones seem to be responsible for the majority of the therapeutic benefits while contributing to control the oestrogenic activity.

This effect is associated with affinity (due to the similarity of their chemical structure) of the isoflavones to estradiol receptors and their capacity to act as agonists and antagonists. Biochanine and formononetine are the main isoflavones present in the red clover.

These molecules are respectively metabolized in vivo in genisteine and diadzeine. Moreover, these four isoflavones have an anti-androgenic activity. It seems that the red clover also has a regulating action on the RNA messenger of progesterone receptor. Black cohosh is approved by the Commission E and the World Health Organization, as a specific treatment to relieve menopause symptoms, and it is largely widespread in Europe.

The triterpenic glycosides, the phenylpropanoids, the organic acids, the polyphenols and the lignanes are the main active components having shown a pharmacological activity. Black cohosh doesn’t seem to have significant direct oestrogenic effects, but rather an anti-oestrogenic effect. Its therapeutic action would also be associated to a serotoninergic effect and as an agonist effect to opiates receptors, which help reducing the physiological stress associated to menopause.

Magnesium comes to potentiate the regulation of the hormonal and nervous functions, thus allowing the reduction of the stress level. The scientific literature emphasizes that the oxidative stress (radical free > antioxidants) is increased in the course of menopause, which is associated with the process of ageing and the development of degenerative diseases.

Viazen Menopause formula includes several sources of antioxidants, in order to counter this process. The alpha-lipoic acid (ALA) is an important antioxidant. Its molecular structure enables to neutralize several types of free radicals. This molecule also has the capacity to recycle other antioxidants, including vitamin E, vitamin C and the antioxidant enzyme glutathion, mainly synthesized by the liver. Supporting liver detoxification process ensures a more effective bio-transformation of circulating oestrogens.

Several components of black cohosh and red clover have also antioxidant activity. In addition, black cohosh, red clover and magnesium offer a protection against the loss of bone mass and thus contribute to prevent the osteoporosis. Lastly, magnesium and the ALA are necessary to energy production (ATP) and so will contribute to reduce general tiredness, often present in the course of menopause.

The ingredients’ synergy of Viazen Menopause is the key of the effectiveness of this SUPERIOR FORMULA.

References :

Wuttke W et al. Maturitas. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. 2003 Mar 14;44 Suppl 1:S67-77. Radowicki S et al. Effectiveness and safety of the treatment of menopausal syndrome with Cimicifuga racemosa dry extract. Ginekol Pol. 2006. Sep;77(9):678-83. Nappi RE et al. Efficiency of Cimicifuga racemosa on climacteric complaints : a randomized study versus low-dose transdermal estradiol. Gynecol Endocrinol. 2005. Jan ;20(1) :30-5. Mahady GB. Black cohosh (Actea/Cimicifuga racemosa): review of the clinical data for safety and efficacy in menopausal symptoms. Treat Endocrinol. 2005;4(3): 177-84. Geller SE, Studee L. Botanical and dietary supplements for mood and anxiety in menopausal women. Menopause. 2007. May-Jun;14(3 Pt 1):541-9 Booth NL et al. The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract. J Altern Complement Med. 2006. Mar ;12(2) :133-9. Overk CR et al. Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). J Agric Food Chem. 2005. Aug 10;53(16):6246-53. Imhof M et al. Effects of a red clover extract (MF11RCE) on endometrium and sex hormones in postmenopausal women. Maturitas. 2006. Aug 20;55(1):76-81. Tice JA et al. Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Colver Extract (ICE) Study: a randomized controlled trial. JAMA. 2003 Jul 9;290(2):207-14. Miquel J et al. Menopause : a review on the role of oxygen stress and favorable effects of dietary antioxydants. Arch Gerontol Geriatr. 2006 May-Jun;42(3):289-306. Pou KM et al. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation. 2007 Sep 11;116(11):1234-41. Beitner H. Randomized, placebo-controlled, double blind study on the clinical efficiency of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin. Br J Dermatol. 2003 Oct;149(4):841-9. Pansini F et al. Oxidative stress, body fat composition, and endocrine status in pre-and postmenopausal women. Menopause. 2007 Aug 9. Nielsen FH et al. Dietary magnesium deficiency induces heart rhythm changes, impairs glucose tolerance, and decreases serum cholesterol in post menopausal women. J Am Coll Nutr. 2007 Apr;26(2):121-32. Hachul de Campos H et al. Sleep disturbances, oxidative stress and cardiovascular risk parameters in postmenopausal women complaining of insomnia. Climacteric. 2006 Aug;9)4): 312-9. Fenichel P. Xénoestrogènes et cancer du sein : De nouveaux facteurs de risque accessibles à la prévention ? Reprod. hum. horm.  2005, vol. 18, n^o 1-2 (56 ref.), pp. 34-42. Sohoni P, Sumpter JP. Several environmental oestrogens are also anti-androgens. J Endocrinol 1998 Sep ;158(3) : 327-39. Olea N et al. Inadvertent exposure to xenoestrogens. Eur J Cancer Prev 1998 Feb ; 7 Suppl 1 : 17-23. www.naturaldatabase.com / www.naturalstandard.com

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